Toward an innovative and cost-effective treatment for major cardiovascular events
Given the important role that inflammation plays in heart
disease, can an existing drug, CD20 monoclonal antibody
(mAb) rituximab (currently used for treating cancer and
lymphoma), be safely repurposed to target inflammation
-based heart disease? Can we do better on top of existing
therapies, which currently only reduce cardiovascular risk by
25-30%? Can said drug treatment improve the recovery of
heart function after a heart attack?
These are some of the hypotheses the RITA-MI 2 consortium
of 13 organisations is setting out to prove with their new
therapeutic strategy. Targeting patients’ immune response
immediately after myocardial infarction (MI), the study is
currently in phase 2 clinical trial.
The RITA-MI2 clinical trial builds on the ground-breaking
work of a unique consortium of doctors and scientists,
following an initial phase 1/2a clinical trial (RITA-MI,
NCT03072199) that established the safety of the rituximab
treatment at the acute phase of MI.
These research partners are now testing this new therapy in
more than 550 patients with acute MI. Based on selective
targeting of a specific immune cell subset, mature B
lymphocytes, the ultimate aim is to improve heart function
recovery and substantially reduce the progression to heart
failure after MI.
The project in numbers
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this research could help solve a significant unmet need in modern heart treatment.
RITA-MI 2 will conduct a phase 2b randomised double-blind placebo-controlled clinical trial to assess the impact of B cell depletion with the CD20 mAb rituximab drug on left ventricular dysfunction and cardiac remodelling after acute MI.
The study has three main aims and objectives :
Prove core concept that rituximab improves heart function in STEMI patients
Assess impact of the drug on vascular inflammation
Better understand the immunopharmacology and cardioprotective mechanisms of rituximab
The RITA-MI2 trial French CRA team sent a newsflash to all French recruiting centres in July 2022. Have a look ! Newsflash 22 07 2022
🎉The RITA-MI2 clinical trial has been launched today at Bichat Hospital, Paris.🏥👩⚕️ More information to come